Sigma receptor
CLASS OF CELL SURFACE RECEPTORS RECOGNIZED BY ITS PHARMACOLOGICAL PROFILE
Sigmaergics; Sigmaergic; Sigmamimetic; Sigmamimetics; Sigma agonist; Sigma antagonist; Sigma receptors
Sigma receptors (σ-receptors) are protein cell surface receptors that bind ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine, and siramesine. There are two subtypes, sigma-1 receptors (σ1) and sigma-2 receptors (σ2), which are classified as sigma receptors for their pharmacological similarities, even though they are evolutionarily unrelated.